| Prophylactic Effect of Zonisamide in Postoperative Seizures |
|
Kwan-Sung Lee, Won Il Joo, Seok-Gu Kang, Seong-Rim Kim, Jong Tea Kim, Jae Taek Hong, Ji-Ho Yang, Jae Geun Ahn, Sin-Soo Jeun, Chun-Kun Park |
|
Department of Neurosurgery, The Catholic University of Korea, College of Medicine, Kangnam St. Mary's Hospital, Seoul, Korea Department of Neurosurgery, The Catholic University of Korea, College of Medicine, St. Mary's Hospital, Seoul, Korea Department of Neurosurgery, The Catholic University of Korea, College of Medicine, Uijeongbu St. Mary's Hospital, Uijeongbu, Korea Department of Neurosurgery, The Catholic University of Korea, College of Medicine, Holy Family Hospital, Bucheon, Korea Department of Neurosurgery, The Catholic University of Korea, College of Medicine, Inchon St. Mary's Hospital, Incheon, Korea Department of Neurosurgery, The Catholic University of Korea, College of Medicine, St. Vincent Hospital, Suwon, Korea Department of Neurosurgery, The Catholic University of Korea, College of Medicine, Daejeon St. Mary's Hospital, Daejeon, Korea Department of Neurosurgery, The Catholic University of Korea, College of Medicine, St. Paul Hospital, Seoul, Korea |
|
|
| Abstract |
Objective
This study conducted to evaluate the preventive effect of zonisamide for postoperative seizure.
Method: This prospective and observational study included patients without preoperative seizure, who underwent craniotomies
for brain tumors (n=25), cerebrovascular diseases (n=44), brain trauma (n=44) and cerebral abscess (n=2). Zonisamide (100
mg twice a day) was administered after craniotomy for up to six months. Thereafter the patients were followed for at least 18
months.
Results
115 patients were selected by inclusion/exclusion criteria from 8 hospitals for this study. Six patients (5.2%) experienced seizure postoperatively. They included two patients with traumatic brain injury, two with brain tumor, one with cerebral
hemorrhage, and one with cerebral abscess. Time interval from the start day of zonisamide administration to the day of first day was 1, 2, 4, 5 and 15months, respectively. One patient had dizziness on zonisamide medication. Skin rash was the most common
adverse event.
Conclusion
This data suggests that prophylactic zonisamide therapy could be safe and acceptable for prevention of postoperative seizures. |
| Key Words:
Anti-epileptic drugs, Prophylactic, Zonisamide, Craniotomy. |
|
PDF Links
Full text via DOI
Download Citation
