| Relevance between Decreased Platelet Activity and Expansion of Intracerebral Hematoma |
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Jong Gon Lee, Joon Cho, Chang-Taek Moon, Sang Woo Song, Hong Gee Roh |
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Department of Neurosurgery, Radiology, Konkuk University School of Medicine Seoul, Korea |
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| Abstract |
Objective
To clarify the rate of hematoa expansion in spontaneous intracerebral hematoma (ICH) patients with decreased platelet activity by platelet function test.
Methods
Thirty-five spontaneous intracerebral hematoma patients who were operated during February 2011 and March 2013 were reviewed. Platelet function test was done in all the patients by multiple electrode aggregometry (MEA), and this test was targetted on the aspirin and P2Y12 receptor inhibitiors. Patients were categorized into the group who had been taking aspirin and/or clopidogrel and the group who had not, and the rate of hematoma was checked in these groups. The rate of hematoma expansion was also checked in the patients with lowered platelet function test regardless of their anti-platelet medication history.
Results
Post-operative hematoma expansion rate was significantly higher in patients with decreased platelet activity by platelet function test, regardless of the antiplatelet medication history (p=0.0107). The bleeding risk was 9 times higher compared to that of the patients with normal platelet activity by platelet function test (Odd ratio=9.625).
Conclusions
The risk of ICH expansion was higher in patients with decreased platelet function by MEA, regardless of their antiplatelet medication history. Platelet function test is considered to be a reasonable guidence in predicting the prognosis of ICH patients. |
| Key Words:
Intracerebral hematoma, Platelet function, Aspirin, Clopidogrel. |
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