| Diffusion Tensor Imaging Characterization of Radiation-Induced white Matter Changes Resulting from Stereotactic Radiosurgery |
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Sung Baek Hue, Jun Bum Park, Sung Ho Park, Eun Suk Park, In Uk Lyo, Soon Chan Kwon, Han Yoo Seong, Hong Bo Sim |
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Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea |
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| Abstract |
Objective
we present our initial experience with using diffusion tensor imaging (DTI) to quantify the extent of radiation-induced
white matter injury after stereotatic radiosurgery (SRS).
Materials and Methods: Fourteen Stereotactic Radiosurgery (SRS) patients were enrolled in this study. The apparent diffusion
coefficient (ADC) and fractional anisotropy (FA)values for each region of interest (ROI) were measured and compared between
the tumoral regions, regions irradiated with ≥12Gy, and normal regions for each patient.
Results
In the tumoral regions, the ADC values showed an 8.3% increase (p=0.234) and the FA values decreased by 2.7%
(p=0.734) as compared to before SRS. In the ≥12Gy regions, the ADC values after SRS gave 2.3% increment value (p=0.129)
and there was a 1.6% reduction in FA values (p=0.734).
Conclusion
We found no differences in the ADC and FA scores for the non-irradiated white matter regions, and only a small percentage change in the white matter ADC and FA scores detected with DTI analysis. |
| Key Words:
Diffusion tensor image (DTI), Sterotactic radiosurgery (SRS), Apparent diffusion coefficiect (ADC), Fractional anisotropy (FA). |
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