| Cardiac Myxoma and Myxosarcoma Causing Cerebral Metastasis treated with GKRS - Report of 3 Cases |
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Yeon Heo, Do Hoon Kwon, Jeong Hoon Kim, Doo Hee Lee |
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Department of Neurosurgery, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea |
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| Abstract |
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Cardiac myxoma and myxosarcoma are exceptionally rare and distinct disease entities that can metastasize to the brain. However, there are no well-established treatments for cerebral metastasis caused by cardiac myxoma and myxosarcoma. We here report cases 2 of cardiac myxoma and 1 case of cardiac myxosarcoma that subsequently caused cerebral metastasis. Case 1, diagnosed as a cardiac myxoma, underwent gamma knife radiosurgery (GKRS) to treat multiple brain metastatic lesions. During follow-up periods, the target tumors decreased in volume. 4 years later, follow-up MRI showed fusiform vascular dilatation in the cerebral arteries. Case 2, also diagnosed as a cardiac myxoma, underwent surgical resection to treat two metastatic lesions in left frontal and parietal lobes. After surgery, the patient underwent GKRS to treat remained lesions. During follow-up period, new lesion was developed. And the new lesion was also treated with GKRS. Case 3, diagnosed as a cardiac myxosarcoma, underwent GKRS to treat two metastatic lesions. But repeated local and new tumor recurrences were observed. The patient subsequently underwent additional GKRS to treat recurred lesions but primary cardiac lesion was increased in size and died of heart failure. Effective local tumor control was seen in case 1 and 2. Also, it is thought that GKRS is helpful to patients considering the poor prognosis of myxosarcoma. |
| Key Words:
Gamma knife radiosurgery, Intracranial metastasis, Myxoma, Myxosarcoma, Aneurysm. |
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