| Fractionated Radiosurgical Hypophysectomy for Refractory Pain in Patient with Recurrent Glioblastoma Multiforme |
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Mi Sun Kim, Je Beom Hong, Joopyung Kim |
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Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea Department of Radiation Oncology, CHA Bundang Medical Center, CHA University, Seongnam, Korea |
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| Abstract |
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Intractable cancer pain was apparently managed with hypophysectomy more than five decades ago. However, the procedure was associated with serious postoperative complications including panhypopituitarism, diabetes insipidus, chemical meningitis, visual dysfunction, and hypothalamic insult. As an alternative to surgical or chemical interventions, radiosurgical hypophysectomy has been used to control intractable cancer pain without serious complications. However, in a 50-year-old patient treated with 60Gy concurrent chemoradiotherapy and Gamma knife radiosurgery for recurrent glioblastoma multiforme, the adverse effects of re-irradiation as well as pain control were minimized using fractionated radiosurgical hypophysectomy. |
| Key Words:
Fractionated radiosurgical hypophysectomy, Recurrent glioblastoma multiforme, Opioid-refractory pain. |
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