| The Effect of Gamma Knife Radiosurgery for Large Volume Metastatic Brain Tumors |
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Ji Young Cho, In Uk Lyo, Young Song, Doo Hee Lee, Soon Young Kim, Yang Kwon, Jung Hoon Kim |
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Department of Neurological Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea |
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| Abstract |
Objective
The purpose of this retrospective study is to evaluate the effect of Gamma Knife Radiosurgery (GKRS) in the treatment for the large volume (>13500mm3) metastatic brain tumors.
Method: From May 1990 to August 2005, 99 cases of large volume metastatic brain tumors were treated by GKRS. Mean volume of lesion was 21,655mm3 (range: 13,500-68,585mm3). Mean marginal dose was 23.4Gy (range: 10-50Gy).
Results
Eighty three patients had already died and the mean survival period after GKRS was 11.6 months. Ten patients after GKRS are still alive with 8.5 months of median follow-up period. Tumor control rate was 75.6%, 65 patients among 86 patients. Local recurrence rate was 24.4%, 21 patients among 86 patients. Delayed radiation change was seen in 10.0% on follow-up MR images.
Conclusion
GKRS in the treatment for the large volume metastatic brain tumor seems to be effective as primary and/or adjuvant therapy compared with whole brain radiotherapy and/or steroid therapy. |
| Key Words:
Metastasism Brain tumorm Gamma Knife Radiosurgery. |
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