Image-Guided Stereotactic Radiosurgery with Cyberknife for Pituitary Adenomas??Early Results

Kim, Hoon; Kim, Young Woo; Joo, Won Il; Chough, Jeoung Ki; Lee, Kyoung Jin; Rha, Hyoung Kyun; Park, Hae Kwan

Original article

Journal of the Korean Society of Stereotactic and Functional Neurosurgery 2007;3(1):48-52.
Published online June 30, 2007.

Image-Guided Stereotactic Radiosurgery with Cyberknife for Pituitary Adenomas??Early Results

Hoon Kim, Young Woo Kim, Won Il Joo, Jeoung Ki Chough, Kyoung Jin Lee, Hyoung Kyun Rha, Hae Kwan Park

Department of Neurosurgery, Catholic Neuroscience Center, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Neurosurgery, Holy Family Hospital, The Catholic University of Korea, Bucheon, Korea

Abstract

Objective
This study demonstrates the clinical usefulness of image-guided stereotactic radiosurgery with Cyberknife system in patients with pituitary adenomas.
Methods
13 patients with pituitary adenomas received Cyberknife radiosurgery. The patients consisted of 8 with non-functioning adenomas, 1 with prolactin-producing adenomas, 4 with GH-producing adenomas. The volume of the tumors ranged from 0.14 to 10.54cm3 (mean：2.80cm3 ). The marginal irradiation dose ranged from 17 to 24Gy (mean：non-functioning adenomas 20.1 Gy, functioning adenomas 19.6G). The median follow-up period after radiosurgery was 13 months (6-26months). The changes in the tumor volume, visual acuity, hormonal function, and complications by this therapy were analyzed in each case.
Results
The tumor control rate was 100%. Endocrinological imporvement was achieved in 100% of functional adenomas. Endocrinological normalization was achived in 40% of functional adenomas. No complication occurred related to the therapy.
Conclusion
Cyberknife radiosurgery is a safe and effective therapy in selected patients with pituitary adenomas. However, despite encouraging early results, more long-term information and a larger number of cases is needed to determine treatment efficacy and late toxicity.

Key Words: Pituitary adenoma, Radiosurgery, Cyberknife.