Journal of the Korean Society of Stereotactic and Functional Neurosurgery 2011;7(1):22-26.
Published online June 30, 2011.
Therapeutic Efficacy of Wnt3a-Secreting Fibroblast Transplantation in a Rat Model of Parkinson's Disease
Hyung Ho Yoon, Joongkee Min, Yong Hwan Kim, Seong Who Kim, Onyou Hwang, Sang Ryong Jeon, Jeong Hoon Kim
Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, KoreaDepartment of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN, USA
Abstract
Objective
s: This article suggests less invasive and safer method of subcutaneous tunneling and insertion of distal part of electrode and extension cables for Deep Brain Stimulation using a lead cap.
Methods
After securing the electrode on the margin of burr hole, the distal end of electrode was connected to the lead cap and fixed with a setscrew. And then we made a pocket in the loose connective tissue of scalp to put the remained distal part of electrode. The end of the electrode which was covered with the lead cap was deeply pushed in the subcutaneous pocket. The operation was finished by suturing layer by layer. In the step of connecting between the electrode and the extension connector under general anesthesia, we just made an incision on protruded cap site, pulled the cap out, and made a tunnel between the incision site and the subclavicular site for Implanted Pulse Generator (IPG). Through the tunnel, the extension cable was inserted to the incision site and connected with the end of electrode.
Results
Patients’ age was 61 year-old in average. 33 Patients were Idiopathic Parkinson’s disease, 9 essential tremor, and 2 dystonia. One patient developed fracture of extension cable two months after the operation. No other hardware related complications including skin erosion were reported.
Conclusions
This technique doesn’t need to open the burr hole site again to connect with the extension cable. Additional small incision on parietal scalp might help save the operation time and avoid skin erosion.
Key Words: Cell transplantation, 6-Hydroxydopamine, Tyrosine hydroxylase, Wnt, Wnt3a-secreting fibroblasts.
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